OBJECTIVE To improve the in vitro dissolution of nimesulide by preparing nimesulide solid dispersion with hot melt extrusion (HME) technology. METHODS Using PVP-VA64，PVP K30 or PVA-PEG (Kollicoat IR) as hydrophilic carrier，nimesulide solid dispersion was prepared by hot melt extrusion and characterized by drug dissolution， DSC， XRD and FTIR. RESULTS Nimesulide exhibited rapid in vitro dissolution from the solid dispersion using PVP-VA64 as carrier. The cumulative release rate was 81% in 10 min， much faster than its physical mixture (only 37% in 1 h). The results of DSC and FTIR showed that nimesulide was amorphously dispersed in the carrier．CONCLUSION Hot melt extrusion technology is suitable for preparing nimesulide-PVP-VA64 solid dispersion， which can significantly increase drug dissolution．
ZHAO You-man, ZHAO Hui -ying, MA Chi.
Preparation of Nimesulide Solid Dispersion by Hot Melt Extrusion Technology[J]. Chinese Pharmaceutical Journal, 2013, 48(3): 185-188 https://doi.org/10.11669/cpj.2013.03.007
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